The short term challenge with Taxol is not the medication, but the solvent (called Cremophor) used to create an injectable solution. Solvent-related hypersensitivity reactions are relatively common, so Kathy's pre-chemotherapy medications included:
*Dexamethasone 20 mg IV 30 minutes prior to chemotherapy.
*Diphenhydramine (Benadryl) 25-50 mg IV 30 - 60 minutes prior to chemotherapy. 50 mg for first dose. May reduce dose to 25 mg on subsequent doses if tolerated
*Famotidine (Pepcid) 20 mg IV infuse over 15 minutes. 30 minutes prior to chemotherapy.
She had no reaction of any kind, so tomorrow's Taxol dose will include 25mg of Diphenhydramine, yielding less Benadryl-induced sleepiness.
Her usual pattern of chemotherapy, one good day, one moderate day, two bad days, then back to good days has been replaced with chemotherapy followed by good, good, and good days. Since we're preparing our Wellesley house for sale (goes on the market April 1) as part of our move to a farm property in Sherborn, Massachusetts, she needs all the energy she can get. Our nights and weekends are filled with painting, cleaning, and boxing.
Her mood is good, our hope for cure is strong, and our optimism for an American Gothic future keeps us going every day.
I'm so glad to hear that Kathy's response to the chemo has improved. She sounds like she's definitely a fighter, and I'm sure the fact that you have such a strong partnership is playing a big role in her progress.
ReplyDeleteBest of luck!
Hi, really pleased the new chemo is ok. i start that next friday so i always check with you to what i'm in for.the farm sounds great can't wait to see photo's.
ReplyDeleteAlison
Encouraging progress! It's great to see that the medical details help other readers with similar conditions. Best wishes most of all on Kathy's recovery, but also on the house prep, and may you have a rapid sale.
ReplyDeleteDavid
Good luck and God bless
ReplyDeleteRohan
Having just moved ourselves, after 17 years in the same house, I know you and Kathy are in the midst of an "adventure." For us, every object now looks very strange in its new context. Doing so in the middle of your Cancer Journey is a truly courageous undertaking. Here's hoping that the farm will be a very special place for you both.
ReplyDelete